Scientific foundation
Research spanning molecular and cellular biology, GPCR and G protein signaling, epithelial polarity, vesicle trafficking, and translational disease biology.
Peer-reviewed research and perspectives, 2010–2024.
Full record on Google ScholarHow iPSC-derived models, microphysiological systems, and computational tools may improve prediction of human drug safety and efficacy—and the remaining challenges of scalability, standardization, reproducibility, and genetic diversity.
Read paperA perspective on the emerging role of human cell models, organoids, microphysiological systems, AI, and computational biology in making preclinical development more clinically predictive.
Read paperPatient genetics and cellular studies connect EXOC2 dysfunction, impaired exocytosis, and disrupted cilia localization to severe neurodevelopmental disease.
Read paperCRISPR/Cas9, high-speed TIRF microscopy, proteomics, and single-molecule imaging reveal how the mammalian exocyst assembles and functions as a dynamic two-part complex.
Read paperHow Par3 recruits the exocyst near tight junctions, enabling basolateral protein delivery, maintaining PI3K–Akt survival signaling, and preventing apoptosis.
Read paperA review of mechanisms that maintain epithelial integrity, architecture, and function, including mechanical sensing, YAP/TAZ signaling, cell extrusion, and cell competition.
Read paperHow KIF14 tethers Radil to microtubules to regulate integrin activation and cell adhesion, and the role of Radil in migration, invasion, and metastasis.
Read paperA signaling mechanism connecting GPCR activation with cell–matrix adhesion through Gβγ, Rap1a, and Radil.
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